Dysfunctional and Senescent Immune Cells in Bone Marrow as a Cause of Age-Associated Lineage Skewing of Hematopoietic Stem Cells

The immune system declines with age for a range of reasons. The thymus atrophies, reducing the supply of new T cells; persistent infection by cytomegalovirus causes cells to become uselessly specialized rather than ready to tackle new threats; and the hematopoietic stem cells responsible for generating immune cells become damaged, inactive, and dysfunctional. One of these forms of dysfunction is that hematopoietic stem cells begin to generate too many myeloid cells and too few lymphoid cells, the so-called myeloid skew. The cause of this skewing in cell production is much debated, but researchers have found that chronic inflammation plays a role. Naturally, nowadays whenever inflammation appears to be an important aspect of any age-related dysfunction, attention turns towards senescent cells. Lingering senescent cells accumulate with

From https://www.fightaging.org/archives/2019/04/dysfunctional-and-senescent-immune-cells-in-bone-marrow-as-a-cause-of-age-associated-lineage-skewing-of-hematopoietic-stem-cells/

from
https://healthnews010.wordpress.com/2019/04/27/dysfunctional-and-senescent-immune-cells-in-bone-marrow-as-a-cause-of-age-associated-lineage-skewing-of-hematopoietic-stem-cells/