Tackling Amyloid-β Oligomers by Interfering in Specific Interactions Necessary to Protein Aggregation

The present consensus on the the development of Alzheimer’s disease is that it starts with the accumulation of amyloid-β, though there are many competing theories as to why only some people exhibit this problem to a great enough degree to produce pathology. The biochemistry of oligomers supporting amyloid-β causes sufficient disarray in brain metabolism to set the stage for neuroinflammation, malfunction of immune cells in the brain, and aggregation of altered forms of tau protein into neurofibrillary tangles that cause most of the damage and cell death in the later stages of the condition. The failure to improve outcomes via attempts to remove amyloid-β from the brains of Alzheimer’s patients may be a case of too little, too late, but there is still good

From https://www.fightaging.org/archives/2019/04/tackling-amyloid-β-oligomers-by-interfering-in-specific-interactions-necessary-to-protein-aggregation/

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https://healthnews010.wordpress.com/2019/04/26/tackling-amyloid-%ce%b2-oligomers-by-interfering-in-specific-interactions-necessary-to-protein-aggregation/