To What Degree is Chronic Inflammation the Cause of Thymic Involution with Age?

The thymus is vital to the function of the adaptive immune system. It is where T cells mature after their creation as thymocytes in the bone marrow, acquiring the necessary tolerance and function to venture forth into the body and defend it against pathogens, cancerous cells, and senescent cells. Unfortunately the thymus declines in size with age, its active tissue replaced with fat, in a process known as thymic involution. The consequence of this is an ever smaller supply of new T cells, ready to tackle threats. The adaptive immune system becomes ever less functional as a result, its limited set of cells uselessly specialized to threats such as cytomegalovirus, and otherwise ever more damaged and dysfunctional, lacking replacements. A broad spectrum of efforts in the research

From https://www.fightaging.org/archives/2019/04/to-what-degree-is-chronic-inflammation-the-cause-of-thymic-involution-with-age/

from
https://healthnews010.wordpress.com/2019/04/20/to-what-degree-is-chronic-inflammation-the-cause-of-thymic-involution-with-age/